The above data highlight three key changes induced by high titers of FU-CJD agent in re-arrested neuronal SEP cells: (1) enormous elevations of IFN-β RNA, (2) significantly diminished transcription of host PrP mRNA and protein production, and (3) the reappearance of Tag protein in re-arrested highly infectious cells. Here, PRNP is linked to Creutzfeldt Jacob disease.