ARG1 and endothelial dysfunction: In fact, elevated Arg1 is involved in endothelial dysfunction in a wide range of vascular beds including pulmonary, coronary, aortic, and mesenteric vasculature (Beleznai et al., 2011; Lucas et al., 2013; Toque et al., 2013; Kövamees et al., 2016; Caldwell et al., 2018).