PRRT2 and Hyperglycemia: Sustained hyperglycemia results in several biochemical, metabolic, and vascular abnormalities that are responsible for disease progression, such as production of advanced glycosylation end-products (AGEs) and activation of the protein kinase C (PKC), polyol, and hexosamine pathways, all of which can promote increased production of cytokines and growth factors (Urias et al., 2017; Ighodaro, 2018).