Hyperlipidemia has also been shown to result in increased intracellular calcium and pro-inflammatory cytokine production, which increases the expression of inducible nitric oxide synthase (iNOS), the NOS isoform that produces cytotoxic quantities of nitric oxide (NO) as an immune defense mechanism (Bogdan, 2015; García-Ortiz and Serrador, 2018; Rao et al., 2021). The gene discussed is NOS2; the disease is hyperlipidemia.