As earlier mentioned, eNAMPT targets Toll-like-receprot-4 (TLR4) a pattern recognition receptor leading to the activation of the NLRP3 inflammasome, which plays a role in inflammatory processes of cardiovascular diseases like atherosclerosis (Luo et al., 2014; Grebe et al., 2018). This evidence concerns the gene TLR4 and cardiovascular disorder.