AGT and hypertensive disorder: It is a long-standing observation that hypertensive patients show elevated serum levels of IgM, IgG or IgA (Ebringer and Doyle, 1970; Gudbrandsson et al., 1981; Suryaprabha et al., 1984; Hilme et al., 1989), but their causative role in hypertension has been shown just recently in Angiotensin-II-treated mouse models (Chan et al., 2015).