Cultured endothelial cells with exposure to eNAMPT presented higher expression of NLRP3-inflammasome related proteins and increased levels of p65 NF-κB and IL-1β (Romacho et al., 2020), supporting the fact that NAMPT enhances vascular inflammation via TLR4 and, e.g., NAMPT itself or IL-1 blockage may function as therapeutic target in cardiovascular diseases. Here, TLR4 is linked to cardiovascular disorder.