Nevertheless, bone morphogenic protein receptor-2 (BMPR2) haploinsufficient rats transduced with 5-lipoxygenase (5-LO), which catalyzes the formation of LTA4 that is hydrolyzed to LTB4, develop severe PAH in frequencies comparable to human BMPR2 mutations (Tian et al., 2019). Here, BMPR2 is linked to pulmonary arterial hypertension.