Furthermore, evidence of increases in the transcription factors Snail, Slug, and Zeb 1/2 in ECs has also been described in cancer biology with effects on tumor growth, angiogenesis, and gene expression unrelated to EndMT (Hultgren et al., 2020; Rong et al., 2020; Cabrerizo-Granados et al., 2021). This evidence concerns the gene SNAI1 and neoplasm.