According to Xia et al., 3,3-Diindolylmethane (DIM), obtained from cruciferous vegetables, inhibits the development of interstitial collagen fibrosis, fibronectin and collagen-1 expressions, and local fibroblast activation; it also decreases the phosphorylation of Smad2/3 and upregulates the expression of Smad7, eventually alleviating kidney injury and renal fibrosis. Here, FN1 is linked to renal fibrosis.