The occurrence of myocardial fibrosis is closely related to regulatory cytokines (such as TGF-β, CTGF, and MMP), inflammatory factors (such as TNF-α, IL-1β, IL-6, and IL-10), oxidative stress and other factors that affect the occurrence and development of myocardial fibrosis by regulating the corresponding signaling pathways. This evidence concerns the gene TNF and Myocardial fibrosis.