We speculated that the increase of Bacteroidaceae (family) and Bacteroides (genus) might account for the beneficial role of berberine for NAFLD, because they were positively associated with a higher serum high-density lipoprotein (HDL) and lower levels of ALT, gamma-glutamyl-transferase (GGT), and ferritin (Lang et al., 2020) and negatively correlated with high hepatic fat fraction in patients with NAFLD (Jobira et al., 2021). Here, GPT is linked to metabolic dysfunction-associated steatotic liver disease.