However, in WD- and WD/CCl4-induced mouse models, the levels of free fatty acid uptake-related proteins CD36 and FABP1, lipolysis-related proteins ATGL and HSL, and β-oxidation-related proteins ACSL1 and ACSL5 were not changed significantly and were not altered by the treatment of bicyclol, berberine, and their combination (Figures 3C, D). The gene discussed is PNPLA2; the disease is Wilson disease.