PPARA and metabolic dysfunction-associated steatohepatitis: In contrast, compared with WD-induced steatosis and WD/CCl4-induced NASH model groups, berberine alone did not change the protein expression of PPARα, and it also did not disturb the effect of bicyclol (Figures 3A, B), suggesting that the enhancement of PPARα-mediated β-oxidation is exclusively the mechanism of bicyclol.