ACC catalyzes the fatty acid synthesis related carboxylation of acetyl-CoA to malonyl-CoA, and FAS catalyzes the synthesis of long-chain saturated fatty acids (Mashima et al., 2009; Gathercole et al., 2011), which are involved in de novo syntheses of TG and subsequent occurrence and progress of NAFLD (Alves-Bezerra and Cohen, 2017). The gene discussed is FAS; the disease is metabolic dysfunction-associated steatotic liver disease.