However, Attard et al. found that there was no significant difference in PFS by comparing A + E and E-A (5.7 vs 5.6 months, p = 0.22), and the frequency of grade 3 hypertension (10 vs 2%) and increased ALT (6 vs 2%) or AST (2 vs 0%) was more frequent in the A + E group. Here, GPT is linked to hypertensive disorder.