Notably, patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M variant is the commonest inherited determinant of NAFLD as it is associated with progression of NAFLD, NASH, and NAFLD-related HCC (Dongiovanni et al., 2015; Eslam et al., 2018; Seko et al., 2018; Trépo and Valenti, 2020). This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatohepatitis.