It has been shown that inhibition of this mechanism by antibodies against CD40L or genetic manipulation, decreases the effects of diet on steatosis, adipose tissue accumulation and insulin resistance (Poggi et al., 2011), acting on hepatic very low density lipoprotein (VLDL) secretion and genes regulating lipid balance (Villeneuve et al., 2010). This evidence concerns the gene CD40LG and Insulin resistance.