HSD17B13 gene encodes for an enzyme that concentrates lipid droplets in hepatocytes: loss-of-function variants in HSD17B13 result in higher protection against liver inflammation, cirrhosis, and HCC (Trépo & Valenti, 2020; Choudhary and Duseja, 2021). The gene discussed is HSD17B13; the disease is hepatocellular carcinoma.