ERBB2 and neoplasm: Parameter variability was included on the antibody tumor vasculature permeability rate (mean: 0.001 cm h−1, SD: 0.00043 cm h−1, range 0.002–0.005 cm h−1), tumor blood volume fraction (mean: 0.12, SD: 0.04, range 0.07–0.2), antibody diffusion rate (mean: 0.00047 cm2 h−1, SD: 0.00017 cm2 h−1, range 0.0003–0.0007 cm2 h−1), HER2 antigens per cell (mean: 1.5E6, SD: 2.8E5) and HER2 internalization/degradation rate (mean: 0.049 h−1, SD: 0.033 h−1, range 0.027–0.12 h−1).