EGFR and neoplasm: Obviously, EGFRIs inhibit both EGFR overexpressed in tumor cells and the one expressed in normal cells of the epidermis. EGFR inhibition induces the expression of chemokines that enhance skin inflammation through leukocyte recruitment, vascular dilation, and edema (Segaert and Van Cutsem, 2005; Lacouture, 2006).