ACE2 and COVID-19: It was also predicted that COVID-19 severity would vary around the world since the prevalence of the ACE2 genetic variants was significantly different in various ethnic groups (Benetti et al., 2020; Gemmati and Tisato, 2020; Ambrocio-Ortiz et al., 2021; Bakhshandeh et al., 2021; Biswas, 2021c; Choudhary et al., 2021).