NLRP3 and inflammatory bowel disease: However, aberrant activation of NLRP3 inflammasome has been reported to promote the development of several human diseases, including gout, type 2 diabetes (T2D), inflammatory bowel disease (IBD), atherosclerosis, neurodegenerative diseases and others (Martinon et al., 2006; Bauer et al., 2010; Duewell et al., 2010; Masters et al., 2010; Wen et al., 2012; Heneka et al., 2013; Guo et al., 2015).