Murine BMDMs were first primed with LPS, then transfected with double-stranded DNA analog poly (A/T) to induce the AIM2 (Absent In Melanoma 2) inflammasome activation or infected with S. typhimurium to induce the NLRC4 (NLR Family CARD Domain Containing 4) inflammasome activation or stimulated with C3 toxin to induce the Pyrin inflammasome activation. The gene discussed is MEFV; the disease is melanoma.