Furthermore, pharmacological inhibition of hedgehog signaling with GDC potentiates PTX-induced mitochondrial damage (Figure 4), ROS accumulation (Figure 5), abnormal mitosis and apoptosis in EGFR WT NSCLC cells (Figure 3), suggesting that hedgehog signaling may play a significant role in modulating PTX sensitivity. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.