Further study demonstrated that a mutant EPO (MEPO) shifted microglia toward M2 polarization by promoting JAK2/STAT3 activation and inhibiting the expression of C/EBPβ at 14 days after cerebral ischemia-reperfusion in middle-aged (9-month-old) mice (Wang et al., 2021). This evidence concerns the gene EPO and Cerebral ischemia.