SORL1 and Alzheimer disease: In particular, rs1800795 (IL6), rs62182086 (PNKD, PNKD Metallo-Beta-Lactamase Domain Containing), rs11218343 (SORL1), rs3745453 (ZSWIM4), rs1491942 (LRRK2, Leucine Rich Repeat Kinase 2) and female sex appeared as the most significant variables for predicting AD risk (Table 4).