In particular, rs1800795 (IL6), rs62182086 (PNKD, PNKD Metallo-Beta-Lactamase Domain Containing), rs11218343 (SORL1), rs3745453 (ZSWIM4), rs1491942 (LRRK2, Leucine Rich Repeat Kinase 2) and female sex appeared as the most significant variables for predicting AD risk (Table 4). This evidence concerns the gene ZSWIM4 and Alzheimer disease.