Both regions of the brain are known to be affected by neurodegenerative processes (Ferese et al., 2015; Yacoubian, 2017; Vitanova et al., 2019) and the above-mentioned genes have been associated with neurological disorders mediated by degenerative mechanisms, including LOAD (PLD3), spinocerebellar ataxia (FAT2, PLD3), paroxysmal non-kinesigenic dyskinesia (PNKD) (Nibbeling et al., 2017; Tan et al., 2019; Garone et al., 2020). Here, FAT2 is linked to cerebellar ataxia.