LRRK2 and Parkinson disease: It is worth noting that specific neurodegenerative genotypes may affect the effects of anti-inflammatory drugs in neurodegenerative diseases, for example, regular use of non-steroidal anti-inflammatory drugs can reduce the risk of PD among leucine rich repeat kinase 2 (LRRK2) variant carriers, which causes the most common Mendelian genetic form of PD (San Luciano et al., 2020).