Ye et al. (2016) found that bee venom (BV)-derived phospholipase A2 (bvPLA2) significantly ameliorated motor dysfunction, down-regulated α-Syn, reduced the activation and numbers of microglia, and influenced microglia polarization to the M2 in human A53T α-Syn mutant transgenic (A53T Tg) mice. Camptothecin improves motor performance, reduces loss of neurons in the SN, and inhibits M1 polarization as well as promotes M2 polarization via the AKT/Nrf2/HO-1 and NF-κB signals in PD mice (He et al., 2021). The gene discussed is NFKB1; the disease is Parkinson disease.