Calbindin expression was found to be decreased in both AD and non-AD dementia patients (McLachlan et al., 1987), is decreased in J20 mice (You et al., 2017), and knockout of calbindin-D28k results in deficient synaptic plasticity and spatial working memory impairment (Molinari et al., 1996). This evidence concerns the gene CALB1 and dementia.