OPTN and amyotrophic lateral sclerosis: However, many ALS/FTD-linked proteins are involved in the autophagy pathways (like ubiquilin-2-UBQLN2-, p62/SQSTM1, and optineurin-OPTN-) and in the endosomal sorting complex (like CHMP2B, a core component of endosomal sorting complex required for transport (ESCRT) complexes) (Ling et al., 2013).