For example, we found upregulation of serine arginine-rich protein family (SRs), including SRSF7, SRSF3, SRSF1, SRSF2, SRSF11, and SRSF10 in SEVs from patients with ALS and SRSF1, SRSF11, SRSF2, SRSF5, and SRSF10 in SEVs from patients with FTD. Here, SRSF3 is linked to amyotrophic lateral sclerosis.