For example, we found upregulation of serine arginine-rich protein family (SRs), including SRSF7, SRSF3, SRSF1, SRSF2, SRSF11, and SRSF10 in SEVs from patients with ALS and SRSF1, SRSF11, SRSF2, SRSF5, and SRSF10 in SEVs from patients with FTD. Here, MANF is linked to frontotemporal dementia.