Moreover, upregulation of HNRNPA2B1, Matrin3, and HNRNPA1P48 in SEVs of both patients with ALS and FTD, as well as TARDBP, identified ALS-FTD-related RNA-binding proteins, characteristically deposited in the affected regions of the brain of ALS/FTD (Ling et al., 2013). Here, HNRNPA2B1 is linked to amyotrophic lateral sclerosis.