NFKB1 and Parkinson disease: In PD, data from in vitro, in vivo, and observational studies suggest SPM are able to cross the blood-brain barrier, inhibit microglial activation and decrease induced markers of inflammation, possibly as a result of their ability to downregulate NFκB signaling pathways (Xu et al., 2013, 2017; Tian et al., 2015).