MAPT and Alzheimer disease: The amyloid cascade is the most accepted hypothesis to explain AD pathogenesis with the main hallmarks of AD being neuritic plaques composed of amyloid beta (Aβ) peptides and neurofibrillary tangles (NFTs) made up of hyperphosphorylated microtubule-associated protein (p-tau) (Iqbal et al., 2010; Barage and Sonawane, 2015).