As a result of netrin-1 treatment, there are improvements in cognitive dysfunction in animal models of AD and a prevention of Aβ-induced cell death in AD cell models and Aβ-induced oxidative stress and neuroinflammation (Lourenço et al., 2009; Spilman et al., 2016; Zamani et al., 2019, 2020). This evidence concerns the gene NTN1 and Alzheimer disease.