In this case, the loss of PV+ interneurons promotes, in the schizophrenia model, hyperactivity in the hippocampus and the hyper-responsivity of the dopaminergic system, and this converges to the findings that there is a substantial loss of parvalbumin protein without loss GABAergics neurons in the pilocarpine model (Benes, 2007; Lodge and Grace, 2007; Knopp et al., 2008; Heckers and Konradi, 2015). This evidence concerns the gene PVALB and schizophrenia.