These authors performed a multi-marker study exploring the relationship among systemic inflammation, metabolic derangements, and circulating mitochondrial derived vesicle in physical frailty and sarcopenia, and through a complex modeling defined five biomarkers [two amino acids (phosphoethanolamine and tryptophan), two cytokines (IL1-ra and MIP-1b), and a subunit of complex I of the mitochondrial electron transport chain (NADH:ubiquinone oxidoreductase subunit S3, NDUFS3)] able to discriminate older adults with and without physical frailty and sarcopenia. This evidence concerns the gene CCL4 and sarcopenia.