Like in humans, where women are less likely than men to develop type 2 diabetes (Kautzky-Willer et al., 2016), female mice are more resistant to HFD than males (Oliveira et al., 2015) and manifest improved glucose tolerance, with greater insulin sensitivity in liver, muscles and adipose tissue (Goren et al., 2004). The gene discussed is INS; the disease is type 2 diabetes mellitus.