Considering the presence of hyperphosphorylated and misconformed tau in the pancreatic islets of patients with type 2 diabetes and patients with AD (Miklossy et al., 2010; Martinez-Valbuena et al., 2019), it is likely that glucose homeostasis impairments seen in latter are, at least in part, related to tau loss of microtubule-binding activity. Here, MAPT is linked to Alzheimer disease.