MAPT and Alzheimer disease: However, at least for AD, the presence of tau pathology was described in brain regions known to control peripheral metabolism such as the hippocampus and hypothalamus (Schultz et al., 1999; Ishii and Iadecola, 2015; Soto et al., 2019) but also, surprisingly, in insulin-producing pancreatic β cells (Martinez-Valbuena et al., 2019).