MAPT and type 2 diabetes mellitus: Considering the presence of hyperphosphorylated and misconformed tau in the pancreatic islets of patients with type 2 diabetes and patients with AD (Miklossy et al., 2010; Martinez-Valbuena et al., 2019), it is likely that glucose homeostasis impairments seen in latter are, at least in part, related to tau loss of microtubule-binding activity.