In order to uncover a possible metabolic disorder related to the expression of the mutated human tau protein, we challenged tau KI male mice and their littermate controls with HFD for a period of 12 weeks, to promote the development of metabolic changes, approaching features of human metabolic syndrome or type 2 diabetes (Winzell and Ahren, 2004). This evidence concerns the gene MAPT and type 2 diabetes mellitus.