INS and Insulin resistance: It has been also reported that patients presenting the most common clinical phenotype of FTLD i.e., the behavioral variant or bvFTLD, among which one-half anatomo-pathologically present with tau aggregates (Pressman and Miller, 2014), exhibit increased fasting insulin levels and HOMA-IR index, a marker of insulin resistance, suggesting impaired glucose metabolism (Ahmed et al., 2014).