SNCA and Parkinson disease: About 10% of PD cases are associated with genetic mutations (Selvaraj and Piramanayagam, 2019), which includes: (i) mutation in the SCNA gene that encodes for the alpha-synuclein protein (α-syn) (Bras et al., 2020), (ii) mutations in the LRRK2 gene, which encodes leucine-rich repeat kinase 2, are a cause of autosomal dominant forms of PD (Zimprich et al., 2004; Tolosa et al., 2020), (iii) heterozygous mutations of the GBA1, encoding for lysosomal enzyme glucocerebrosidase (GCase), are a strong risk factor for PD and can lead to α-syn accumulation (Avenali et al., 2020).