An abundance of synaptic vesicle-related proteins like CD9 (exosomes), Clathrin, AP-2 complex, and dynamin (clathrin-mediated endocytosis), dynein, dynactin, and spectrin (retrograde transport), synaptosomal-associated protein 25, vesicle-associated membrane protein 2, and syntaxin-1 (synaptic vesicle fusion) are present in α-syn-containing protein inclusions purified from post mortem brain tissues from dementia with Lewy bodies (DLB) patients (McCormack et al., 2019). The gene discussed is SNAP25; the disease is Lewy body dementia.