Mutations in LRRK2 have been shown to reduce mitochondria trafficking in rat neurons (Godena et al., 2014; Hsieh et al., 2016), impair the mitophagy activity in PD-derived cells (Bonello et al., 2019; Wauters et al., 2020), and increase aggregation of α-syn in mice models and human iPSC-derived dopaminergic neurons (Bieri et al., 2019). This evidence concerns the gene LRRK2 and Parkinson disease.