For instance, mice lacking MeCP2 in somatostatin-positive (SOM+) interneurons develop seizures but display normal memory and social interaction; in contrast, mice lacking MeCP2 in parvalbumin-positive (PV+) interneurons do not exhibit epileptic activity but rather show cognitive deficits (Ito-Ishida et al., 2015). The gene discussed is MECP2; the disease is Cognitive impairment.