Indeed TSPO appeared to be specifically upregulated in astrocytes and microglia (Pannell et al., 2020), but interestingly, its expression was not related to microglia, astrocytes, Aβ, tau neurofibrillary tangles or cortical thickness in post-mortem AD (Gui et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.