For example, a systematic review conducted in 2017 demonstrated that the markers CD68 and major histocompatibility complex (MHC II), acknowledged as markers of microglial activation linked to phagocytosis and antigen-presentation, respectively, were increased, while the expression of CD11b (complement receptor 3) and ionized calcium-binding adapter molecule 1 (Iba1) (Figure 4), associated to microglial motility (Franco-Bocanegra et al., 2019b) were not different between the control and AD cohorts. The gene discussed is AIF1; the disease is Alzheimer disease.