GBP2 and Creutzfeldt Jacob disease: Whilst both markers showed an increase in Creutzfeldt-Jakob disease (CJD) cases, a disease associated with severe astrogliosis, in controls, C3 displayed high non-specific background staining in human tissue, whereas and GBP2 was highly abundant in GFAP+ astrocytes in disease tissue and was completely absent in control tissue (Hartmann et al., 2019).