When adding NfL to measurements of α-syn, Aβ42, Aβ40, or Aβ42/40, the best discriminating panel was formed in differentiating APD and HC with a sensitivity of 100% and specificity of 100%, and combination of NfL, Aβ42, and total tau was proved to be the most reliable panel for differential diagnosis between PD and APD, with equally high diagnostic accuracy. Here, NEFL is linked to Parkinson disease.