The major findings of this study were as follows: (i) 18F-FGA selectively accumulates in infarcted myocardium while rapidly clearing from the rest of the body, (ii) rapid washout of 18F-FGA meant that the optimal imaging time after 18F-FGA injection is 1 h p.i., (iii) 18F-FGA localization in injured myocardium is highest early after occlusion, but significant uptake persists even after 3 days of MI, and (iv) fibronectin is the likely target of glucarate analogs in necrotic myocardial cells. The gene discussed is FN1; the disease is myocardial infarction.