Tregs could be an ideal target for therapies to induce remission of autoimmune disorders.16 IL-2 has been reported to exert beneficial effects for the treatment.12,17–19 Recently, Klatzmann et al. reported the safety, biological and clinical effects of Ld-IL2 in a basket of 11 individual diseases, including RA.20 In the present study, we conducted a randomized, double-blind, placebo-controlled study. This evidence concerns the gene IL2 and autoimmune disease.