2020). In other words, the expression of ANP, BNP and α-MHC was significantly increased in serum of TAC-induced mice, and they was significantly down-regulated after treatment with PAE in the study. Consistent with the previous study (Choy et al. 2018), combined with H&E staining results, we suggested that PAE could alleviate myocardial hypertrophy and improve cardiac function. The gene discussed is NPPA; the disease is cardiac hypertrophy.