For instance, TMZ attenuated fibrosis, apoptosis and exacerbated autophagy in diabetic cardiomyopathy [23]; TMZ had protective effects against HgCl2-induced kidney injury by reducing oxidative stress-mediated [24]; TMZ improved adipogenesis and steatosis in nonalcoholic fatty liver via the AMPK-ChREBP pathway [25]. The gene discussed is MLXIPL; the disease is diabetic cardiomyopathy.