While EGFR and HER2 were basally tyrosine phosphorylated in all cell lines tested, tyrosine phosphorylation of EGFR was dependent on Met kinase activity in three out of seven tested cell lines (OE33, EBC1 and H1993) and tyrosine phosphorylation of HER2 was dependent on Met activity in two lung cancer cell lines tested (EBC1 and H1993) (Fig. 1b). This evidence concerns the gene EGFR and lung cancer.