MAPT and Alzheimer disease: They include the extracellular amyloid plaques, which are primarily formed by deposition of the β-amyloid (Aβ) peptides, which is usually early pathological manifestations of AD, and the intraneuronal neurofibrillary tangles within the dystrophic neurites, which consist of the aggregated and pathologic Tau proteins, and usually occurs in later stages of AD following Aβ accumulation (3).