IL1B and Alzheimer disease: AD-related chronic neuroinflammation at the advanced stages of pathology manifests by microglial production of pro-inflammatory cytokines/chemokines, including IL-1β, IL-6, TNFα, CC-motif chemokine Ligand-5 (CCL5), Macrophage Inflammatory Protein-1α (MIP-1α) and MCP-1 via TLR4, TLR2 and inflammasome NALP3 signaling [31, 33, 58].