In the male saline group, there are 62 total significant relationships with 57 being positive and 5 negative centered on metabolic nodes (hexokinase 1 (HK1), complexes I, II, III, and IV, superoxide dismutase 2 (SOD2), aconitase, citrate synthase (CS) activity, voltage-dependent anion channel (VDAC), as well as phosphatidylinositol binding clathrin assembly protein (PICALM), an Alzheimer’s disease risk protein involved in autophagy and endocytosis. This evidence concerns the gene HK1 and Alzheimer disease.