PICALM and early-onset autosomal dominant Alzheimer disease: In the male saline group, there are 62 total significant relationships with 57 being positive and 5 negative centered on metabolic nodes (hexokinase 1 (HK1), complexes I, II, III, and IV, superoxide dismutase 2 (SOD2), aconitase, citrate synthase (CS) activity, voltage-dependent anion channel (VDAC), as well as phosphatidylinositol binding clathrin assembly protein (PICALM), an Alzheimer’s disease risk protein involved in autophagy and endocytosis.