SOD2 is a prominent node in both male and female saline groups; positively associated with levels of HK1 [50, 51], autophagy proteins p62 and LAMP1 [31], and neurodegenerative disease-associated proteins, PSD95 [41–43] and PICALM [52–55], except that in the female saline group, SOD2 is correlated with complex II but not complex III activity. This evidence concerns the gene PICALM and neurodegenerative disease.