RUNX1 and viral infectious disease: Brass et al. conducted RNAi screens in osteosarcoma cells (U2OS) infected with influenza A/Puerto Rico/8/34 (H1N1) (PR8), and Karlas et al. performed RNAi screens in a human alveolar epithelial cell line (A549) with influenza A/WSN/33(H1N1) and the pandemic A/Hamburg/04/2009(H1N1) virus infection, and both of the groups identified RUNX1 as one of the targets [31, 32], which indicated that RUNX1 might promote IAV infection.