Their results indicated that prophylactic G-CSF administration can considerably shorten the duration (1.4 ± 1.7 days vs. 2.9 ± 1.9 days, P = 0.004) and frequency (48% vs. 83%, P = 0.002) of grade 3 neutropenia [14]. This evidence concerns the gene CSF3 and Decreased total neutrophil count.