Besides, the representative images for HIF-1α, CD31, VEGF, Ki67 and TUNEL staining of tumor sections (Fig. 6D) reflected that Cur@Hb nanoparticles could alleviate tumor hypoxia, inhibit angiogenesis and tumor cell proliferation and promote tumor cell apoptosis, thereby enhancing the efficacy of radiotherapy for hepatoma. The gene discussed is PECAM1; the disease is hepatocellular carcinoma.