GSTM1 and neoplasm: Moreover, benefit from the combination of oxygen-carrying hemoglobin with polyphenolic curcumin, the nanoparticles could effectively enhance the photoacoustic contrast and better inhibit the infiltration of tumor cells in vivo, which laid a theoretical and experimental basis for the application of Cur@Hb nanomaterials as radiosensitizers for hepatoma radiotherapy and might provide a valuable type of nano-radiosensitizer for radiotherapy of solid tumors.