Besides, the representative images for HIF-1α, CD31, VEGF, Ki67 and TUNEL staining of tumor sections (Fig. 6D) reflected that Cur@Hb nanoparticles could alleviate tumor hypoxia, inhibit angiogenesis and tumor cell proliferation and promote tumor cell apoptosis, thereby enhancing the efficacy of radiotherapy for hepatoma. This evidence concerns the gene HIF1A and hepatocellular carcinoma.