Our data showed that Cur@Hb nanoparticles inhibited tumor cell migration and vascular mimics via inhibiting the expression of EMT-related proteins Twist1, VE-Cadherin and MMP2, and enhanced the radiosensitivity of hypoxic hepatocellular carcinoma through inhibiting cell proliferation, promoting apoptosis and increasing DNA damage. The gene discussed is MMP2; the disease is hepatocellular carcinoma.