JAML and acute promyelocytic leukemia: Besides, Christel Moog-Lutz et al. found out that AMICA1 mRNA was up-regulated in all-trans retinoic acid-treated acute promyelocytic leukemia cells, and the mRNA is also up-regulated in myeloid leukemia cells during induced differentiation through granulocytic and monocytic pathways [17], but the mechanism is still unclear.