In another study, Huang and colleagues reported that Treg cells induced IL-17RB expression in BC cells by secreting TGF-β1 and activating the Smad2/4/3 signaling pathway in the tumor-draining LNs (TDLNs), thereby increasing proliferation, angiogenesis, and metastasis of cancer cells. The gene discussed is TGFB1; the disease is breast cancer.