Miscellaneous variants in CATSPER1, SPATA16, and TEX11 genes are identified that play important roles in pathogenesis of sperm morphology (teratozoospermia), sperm motility parameters (asthenozoospermia), or sperm number (oligozoospermia or azoospermia) in human [12]. The gene discussed is SPATA16; the disease is Azoospermia.