In the present study, we recruited 100 patients with idiopathic male infertility (azoospermia and/or oligospermia) and 100 healthy controls from Iranian Azeri population in order to investigate correlation of CATSPER1 (rs2845570), SPATA16 (rs1515442), and TEX11 (rs143246552) genes polymorphism with idiopathic azoospermia and oligospermia risk. The gene discussed is CATSPER1; the disease is male infertility.