Relative to Control, Tumor mice had higher spleen mass (Fig. 4A), higher burden of total splenic bacteria as detected via FISH staining for global bacterial 16S DNA (Fig. 4B), and higher splenic production of the pro-inflammatory cytokines IL-6, CXCL1, and MCP-1, but lower TNFα (Fig. 4C). The gene discussed is CXCL1; the disease is neoplasm.