We have found that the incidence of AKI in PNS patients is 28.05%, and diabetes, pulmonary infection, albumin ≤ 24 g/L, serum creatinine ≥ 90 μmol/L, blood urea nitrogen ≥ 6.5 mmol/L, uric acid ≥ 390 μmol/L, renal tubular casts are the independently influencing factors of AKI in PNS patients. The gene discussed is ALB; the disease is acute kidney injury.