We assessed CNVs in these lymphomas and in accord with recent studies (39,40), the karyotypic landscape from the Trp53-/-Prkce+/+ tumours displayed aneuploidy for multiple chromosomes, including chromosome 4 and 5 gain and chromosome 13 loss (Fig. 6B), aneusomies identified also in human lymphoblastic lymphomas (41). Here, PRKCE is linked to lymphoma.