However, a possible reason for the overall lower performance of the system in samples from the MECC study is the ethnicity of the patient population included in this study: This study is a population-based study from northern Israel and has a high proportion of Ashkenazi Jews who have a specific genetic mechanism in familial CRC39 and potentially differences in genetics of sporadic CRC, as evident by a higher proportion of BRAF mutations in CRC.40 This evidence concerns the gene BRAF and colorectal carcinoma.