The expression of genes encoding cytochrome P450 (CYP-450), cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, which are involved in the oxidation of PUFAs to form oxylipins, was investigated to assess their contribution to the differences in the oxylipin profile observed at study entry between normal weight individuals and those living with obesity. The gene discussed is LOX; the disease is Obesity.