NFKB1 and obesity due to melanocortin 4 receptor deficiency: ,20 These have anti-inflammatory actions and have been reported to regulate the infiltration of leukocytes, block interleukin (IL)-1 induced activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and decrease the expression of pro-inflammatory cytokines.21, 22, 23, 24 We previously reported EPA and DHA to increase the concentrations of two endocannabinoids, eicosapentaenoyl ethanolamide and docosahexaenoyl ethanolamide, in scWAT in normal weight individuals but that this effect of LC n-3 PUFAs is impaired in individuals with obesity.13