The mRNA expression of 12-LOX was negatively correlated with body fat % which is concordant with lower proportions of 14-HDHA in individuals living with obesity; however, greater expression of 5-LOX, COX-1 and CYP1B1 was observed in individuals living with obesity which was not concordant with the altered proportion of respective pathway oxylipins in these individuals. The gene discussed is ALOX15; the disease is obesity due to melanocortin 4 receptor deficiency.