We used the ‘insulin secretion’ pPS of variants in eight genes associated with type 2 diabetes risk due to poor beta cell function: MTNR1B, HNF1A, GCK, TCF7L2, TMEM258, ADCY5, SLC3OA8 and ABO [32, 33]. The gene discussed is ADCY5; the disease is type 2 diabetes mellitus.