We found CD1A|CXCL13, CD1A|S100A7L2, IFNA7|CMTM2, IFNA7|CSF3, CAMP|TFR2, this 5‐IRGPs were strongly associated with the prognosis of patients, all of which were protective factors for the prognosis of lung adenocarcinoma. This evidence concerns the gene CXCL13 and lung adenocarcinoma.