We found CD1A|CXCL13, CD1A|S100A7L2, IFNA7|CMTM2, IFNA7|CSF3, CAMP|TFR2, this 5‐IRGPs were strongly associated with the prognosis of patients, all of which were protective factors for the prognosis of lung adenocarcinoma. Here, S100A7L2 is linked to lung adenocarcinoma.