Indeed, ferroptosis inducers, which suppress SLC7A11 expression, have been shown to improve the efficacy of chemotherapy and radiotherapy by increasing the sensitivity of tumor cells to ROS.[4, 44, 45, 46] Given that YY2 could suppress SLC7A11 expression, while further pre‐clinical and clinical investigations are needed, our study highlights the potential of combinatorial therapy using YY2 and chemotherapy or radiotherapy for treating tumors. This evidence concerns the gene YY2 and neoplasm.