SLC7A11 and neoplasm: Together with glutathione peroxidase 4, GSH reduces lipid peroxidases to lipid alcohols, thereby protecting tumor cells from oxidative stress.[1, 4, 5] Importantly, blocking cystine uptake by inhibiting solute carrier family 7 member 11 (SLC7A11), the catalytic subunit of system xc−, could induce ferroptosis and suppress tumorigenesis.[6, 7, 8, 9]