SLC7A11‐mediated cystine uptake is the rate‐limiting step of glutathione synthesis, which is critical for maintaining cellular redox homeostasis, eliminating lipid peroxidation, and thereby suppressing ferroptosis.[1, 2, 5, 7, 37, 42] Upregulation of SLC7A11 has been identified in lung, breast, and colon cancers, where it promotes antioxidant defenses, favors tumorigenesis, and exhibits resistance against chemotherapy.[5, 43, 44] This makes SLC7A11 an attractive target for anti‐tumor therapy. Here, SLC7A11 is linked to malignant colon neoplasm.