Tumor vascular normalization are associated with a large number of cytokines (Figure 12), mainly including two groups: one group is a cytokine that causes characteristic vessel abnormalities (red in Figure 12), including Angiopoietin (Ang); epidermal growth factor receptor (EGFR), focal adhesion kinase, glioblastoma multiforme, human epidermal growth factor receptor 2, hypoxia inducible transcription factor, phosphoinositide‐3‐kinase; placental growth factor, regulator of G protein signaling 5. The gene discussed is ANG; the disease is neoplasm.