Chen and co‐workers fabricated a NO delivery system (NanoNO) that was component of glycol (PEG) polymer surface, and the biodegradable poly(lactic‐co‐glycolic acid) (PLGA) polymer and the NO donor dinitrosyl iron complex core (Figure 14).[94] Low‐dose NanoNO effectively normalized tumor vasculatures, which ameliorated immunosuppressive TME, suppressing metastasis and improving the cancer therapy efficacy of three modalities, including chemotherapy, a vaccine‐based cancer immunotherapy and tumor necrosis factor‐related apoptosis‐inducing ligand‐based biological therapies. The gene discussed is TNF; the disease is cancer.